The researchers from the University of Tübingen have developed a computer model for macrophages and the complex Interaction of different processes in the cells observed. Specifically, it was the alveolar macro-phages in the alveoli for the defense from foreign substances is responsible. You are in the Front line of the body with a Covid-19 infection apart.
The initial situation in the model presented so that the Virus has already penetrated into human Alveolar macrophage and reprogrammed. The result would be, then, that here, henceforth, new viruses are produced. The Simulation showed a possible way how this can be prevented, without affecting the actual functions of the cells.
Multiplying in a bind
“We have first analyzed the composition of the Virus, and it is calculated, what Material is needed for a virus to produce particles,” says the bioinformatics expert Andreas Dräger for the procedure. “If you know that, you can play around with different scenarios and see how the biochemical reactions in the cells of the host during a viral infection.”
At the end, it was revealed that the enzyme guanylate kinase (GK1) plays in the propagation of the Virus in a Central role. If you eliminated it, produced the cell, no new SARS-CoV-2-pathogens and more. “While the multiplication of the virus does not take place without the GK1, you can use the human cell to other biochemical pathways,” said Dräger. The cells can continue with their actual tasks.
The advantage of this is that there are already some of the known inhibitors, which can be used to GK1 slow down. In the next step you want to test now with partners from the Fraunhofer IME screeningport, is already authorised products. May be the result of this is that soon an anti-viral drug is available, with the target already was infections, the procedure can be.